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Fengfu Pharma,headquartered in Hangzhou, China, with 3 production bases in Shandong, Zhejiang and Hebei separately, which have many years of experience in the production of APIs, vitamins and chemical products. These facilities have been certified GMP, ISO, FAMI-QS, KOSHER, HALAL, etc.
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We have complete control over our product development, design, and manufacturing processes, thanks to our advanced equipment, methods, and inspection facilities.
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Our goal is to provide you with quality products and professional services for mutual benefit. We are also willing to work with partners around the world to create a better future together.
Cyclosporine is an immunosuppressive agent used to treat organ rejection post-transplant. It also has use in certain other autoimmune diseases, treatment of organ rejection in kidney, liver, and heart allogeneic transplants, rheumatoid arthritis when the condition has not adequately responded to methotrexate. Also, it is a second-line agent for ALS and graft vs. host disease. It also has other FDA and non-FDA-approved indications.
Polymyxin B Sulfate CAS 1405-20-5
Product: Polymyxin B Sulfate CAS 1405-20-5
Chemical Name: Polymyxin B, sulfate (salt); Polymyxin B; Polymyxin-B-Sulfat; Sulfato De Polimixina B; Polymyxin B (PMB); PMB; Polymyxin B sulfate USP; Polymyxin B Sulfate 1405-20-5; Einecs 215-774-7;
CAS No.: 1405-20-5
Parecoxib Sodium CAS 198470-85-8
Product: Parecoxib Sodium CAS 198470-85-8
Alternative Name: Parecoxib Sodium; Parecoxib; Parecoxib Sodium API; Parecoxib Sodium API;
Chemical Name: 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide sodium salt
Molecular formula: C19H18N2O4S·Na
Molecular mass: 392.409
Vonoprazan Fumarate CAS 1260141-27-2
Product: Vonoprazan Fumarate TAK-438
Another name: TAK438; TAK-438
CAS No.: 1260141-27-2
Application: It effectively terminates the secretion of gastric acid, thereby achieving acid suppression
Product Category: Gastrointestinal API, Pepsin digestive enzyme API, Pancreatin digestive enzyme API
Product: Fusidic Acid 6990-06-3
Chemical Name: Fusidic acid; Fusidic Acid API; Fusidic Acid Active Pharmaceutical Ingredient; CAS 6990-06-3; Acide Fusidique; Acido Fusidico; 6990-06-3;
CAS No.: 6990-06-3
Physical characteristics: white powder
Molecular Formula: C31H48O6·1/2 H2O
Vonoprazan Fumarate CAS 881681-01-2
Product: Vonoprazan Fumarate CAS 881681-01-2
Chemical Name: 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate
Another name: TAK438; TAK-438; MFCD18633280; 1260141-27-2 TAK-438 AKSci J97352; Fumarat Vonoprazana; Vonoprazan Fumarate-D3; N-methyl-1-(3-pyridyl sulfonyl)-1H-pyrrole-3-methanamine; 1-(5-(2-Fluorophenyl); AB457904 CAS 881681-01-2;
Product: Sodium Fusidate CAS 751-94-0
Chemical Name: Fusidate De Sodium; Fusidato De Sodio; Fuzydyt Alsudium; Natriy Fuzidat; 751-94-0; Fucidina; Fucidine; Fusidatesodium; Fusidin; Fusin; Intertullefucidin; Sodium fusidate reference substance;
CAS No.: 751-94-0
Physical characteristics: A white crystalline powder, and the solvent is a colorless clear liquid.
Product: Bacitracin Zinc CAS 1405-89-6
Another Name: Bacitracina De Zinc; Batsitrazin Tsink; Bacitracina De Zinco; CAS 1405-89-6; 1405-89-6;
Physical characteristics: Pale yellow to brownish-yellow powder; odorless with a bitter taste.
Molecular formula: C66H103N17O16SZn
Product: Lincomycin HCL CAS 859-18-7
Another Name: Lincomycin Hcl; lincomycin hydrochloride; methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride; Lincomycin hydrochloride anhydrous; CAS 859-18-7; 859-18-7; Hidrocloruro De Lincomicina; Hidruklurid Allinkomaisin; Lincocin; Lincomix; Lincomycin Monohydrochloride;
Pazufloxacin Mesilate CAS 163680-77-1
Product: Pazufloxacin Mesylate CAS 163680-77-1
Another Name: Pazufloxacin Methanesulfonate; pazufloxacin mesylate; Pazufloxacin MS; Pazufloxacin MSLT; Pazufloxacin Methanesulphonate; 163680-77-1; Pazufloxacin mesilate; Pazucross; Pazufloxacin (mesylate); Pazufloxaxin methanesulfonate; Pasil; T-3762;
Cyclosporin CAS 59865-13-3 both come as a capsule and a solution (liquid) to take by mouth. Cyclosporine is usually taken once a day. Cyclosporine (modified) is usually taken twice a day. It is important to take both types of cyclosporine on a regular schedule. Take cyclosporine or cyclosporine (modified) at the same time(s) each day, and allow the same amount of time between doses and meals every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cyclosporine or cyclosporine (modified) exactly as directed. Do not take more or less of the medication or take it more often than prescribed by your doctor.
Your doctor will probably adjust your dose of cyclosporine or cyclosporine (modified) during your treatment. If you are taking either type of cyclosporine to prevent transplant rejection, your doctor will probably start you on a high dose of the medication and gradually decrease your dose. If you are taking cyclosporine (modified) to treat rheumatoid arthritis or psoriasis, your doctor will probably start you on a low dose of the medication and gradually increase your dose. Your doctor may also decrease your dose if you experience side effects of the medication. Tell your doctor how you are feeling during your treatment.
Cyclosporine (modified) helps control the symptoms of psoriasis and rheumatoid arthritis, but does not cure these conditions. If you are taking cyclosporine (modified) to treat psoriasis, it may take 2 weeks or longer for your symptoms to begin to improve, and 12 to 16 weeks for you to feel the full benefit of the medication. If you are taking cyclosporine (modified) to treat rheumatoid arthritis, it may take 4 to 8 weeks for your symptoms to improve. Continue to take cyclosporine (modified) even if you feel well. Do not stop taking cyclosporine (modified) without talking to your doctor. Your doctor may decrease your dose gradually.
You may notice an unusual smell when you open a blister card of cyclosporine capsules. This is normal and does not mean that the medication is damaged or unsafe to use.
Cyclosporine (modified) oral solution may gel or become lumpy if it is exposed to temperatures below 68 °F (20 °C). You can use the solution even if it has gelled, or you can turn the solution back to a liquid by allowing it to warm to room temperature (77 °F [25 °C]).
Cyclosporine and cyclosporine (modified) oral solution must be mixed with a liquid before use. Cyclosporine (modified) oral solution may be mixed with room temperature (77 °F [25 °C]) orange juice or apple juice but should not be mixed with milk. Cyclosporine oral solution may be mixed with milk, chocolate milk, or orange juice. You should choose one drink from the appropriate list and try to always mix your medication with that drink.
The Mechanism of Action Of Cyclosporin CAS 59865-13-3
Cyclosporine works to suppress cell-mediated immune reactions. Research has detected no effects on phagocytic function in animals, and it does not cause bone marrow suppression in animal or human models.
The mechanism of action of cyclosporine is as a calcineurin inhibitor, a cytochrome P450 3A4 inhibitor, and a P-glycoprotein inhibitor. Cyclosporin A (CsA) inhibits the synthesis of interleukins (IL), including IL-2, which is essential for the self-activation of T lymphocytes (LT) and their differentiation. Cyclosporine is effective due to specific and reversible inhibition of immunocompetent lymphocytes in the G0 and G1-phase of the cell cycle. The T-helper cell is the primary target, although it may also suppress T-suppressor cells. The LT-B-lymphocyte (LB) co-operation is essential for activation of LB; the latter also gets inhibited. In addition, research has demonstrated that CsA had an inhibiting effect on CD4+ CD25+ Tregs, which might block the host immune tolerance potentiality.
Metabolism: Via hepatic CYP3A4 and is metabolized into a pair of hydroxylated derivatives (AM1 and AM9) and one N-methylated derivative (AM4N).
Enzymes inhibited: CYP3A4 and P-glycoprotein.
Half-Life: 8.4 to 27 hours: The time to peak blood cyclosporine concentrations (Tmax) ranges from 1.5 to 2 hours following oral administration of cyclosporine oral solution USP modified.
Clearance: 5 to 7 mL/min/kg in patients who are recipients of renal or liver allografts while appearing to be somewhat slower in cardiac transplant patients.
Excretion: Mainly bile and feces.
Factors known to influence absorption: Time post-transplant, bile flow, dietary composition, gastrointestinal state, liver function, small bowel length, and vehicle.
Cyclosporine is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is usually taken along with other medications to allow your new organ to function normally. Cyclosporine belongs to a class of drugs known as immunosuppressants. It works by weakening the immune system to help your body accept the new organ as if it were your own.
Take this medication by mouth as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose.
The dosage is based on your weight, medical condition, lab tests, and response to treatment.
Carefully measure the dose using the medicine syringe provided. Do not use a household spoon because you may not get the correct dose. To help improve the taste, you should mix the measured dose with a glass of milk, chocolate milk, or orange juice that is at room temperature. Do not switch the liquid you use often. Make sure to use a glass cup and not a plastic cup. Drink all of the mixture right away. Do not prepare a supply in advance. To make sure you have taken all of the medication, rinse the glass with more liquid, then mix and drink. Consult your pharmacist if you have any questions.
Dry the outside of the syringe after use. Do not rinse it with water. If the syringe must be cleaned, make sure that it is completely dry before using it again.
Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Cyclosporine works quickly to treat extensive or disabling psoriasis. A dermatologist may prescribe it to help a patient gain control of severe psoriasis and then switch the patient to another psoriasis treatment.
Cyclosporine can effectively treat:
● Plaque psoriasis
● Severe guttate psoriasis
● Erythrodermic psoriasis
● Generalized pustular psoriasis
● Palmoplantar psoriasis
If nothing else will control the psoriasis, a patient may continue taking cyclosporine for a year or longer.
Cyclosporine is taken by mouth or given by injection. The oral medication is available either as a liquid or in capsule form. Liquid cyclosporine is available in 50-ml (5000-mg) bottles (100 mg is equal to 1 ml). After being opened, liquid cyclosporine remains usable for two months. Cyclosporine capsules are available in 100-mg, 50-mg, and 25-mg doses.
Liquid cyclosporine can be diluted in milk, chocolate milk, or orange juice. Do not dilute in grapefruit, pineapple, or papaya juice. Use a glass container, not a Styrofoam cup. Stir the mixture well and have your child drink it immediately. After emptying the glass, add more juice or milk and have your child drink that as well, to ensure that he or she is getting the full dose. Do not rinse the measuring syringe in water.
Capsules should be swallowed whole; they can be taken with or without food. Avoid taking this medication with grapefruit, pineapple, or papaya juice.
Cyclosporine should be taken at the same time each day. If your child takes it twice daily, the doses should be 12 hours apart.
Check with your transplant coordinator if you want to change the time of your child's dose. If you are traveling to a different time zone, contact your coordinator for advice about when your child should take his or her medicine.
Who Should Not Take Cyclosporine CAS 59865-13-3
O not take cyclosporine if you have:
● A compromised immune system
● Abnormal kidney function
● High blood pressure
● Cancer, or a history of cancer (other than basal or squamous cell skin cancers)
● Severe gout.
Additionally, do not take cyclosporine if you are:
● Pregnant or breastfeeding
● Undergoing radiation treatment
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies on the relationship of age to the effects of cyclosporine have not been performed in children receiving organ transplants. However, no pediatric-specific problems have been documented to date.
Appropriate studies have not been performed on the relationship of age to the effects of cyclosporine in children with rheumatoid arthritis or psoriasis. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cyclosporine in the elderly. However, elderly patients are more likely to have high blood pressure or age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving cyclosporine.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Our Factory
Zhejiang Fengfu Pharma Co.,Limited engaged in the development, production and marketing of pharmaceutical products, food ingredients, vitamins, intermediates and chemicals.
Fengfu Pharma,headquartered in Hangzhou, China, with 3 production bases in Shandong, Zhejiang and Hebei separately, which have many years of experience in the production of APIs, vitamins and chemical products. These facilities have been certified GMP, ISO, FAMI-QS, KOSHER, HALAL, etc. We have complete control over our product development, design, and manufacturing processes, thanks to our advanced equipment, methods, and inspection facilities.
With key competencies in pharmaceuticals and food health, Fengfu Pharma has established extensive business networks around the world. We have Strategic Marketing Partners respectively in Mumbai and Dubai. We are ready to provide you with our best products and services.
Our goal is to provide you with quality products and professional services for mutual benefit. We are also willing to work with partners around the world to create a better future together.
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