Polymyxin B Sulfate CAS 1405-20-5

Polymyxin B Sulfate (PMB) is an antibiotic that exhibits inhibitory effects on various Gram-negative bacteria, including Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Haemophilus influenzae. It is used for the treatment of bacterial infections such as urinary tract infections, meningitis, blood infections, and eye infections.

Tests	Specifications	Results
Description	White or almost white powder, hygroscopic	Conforms
Identification	LC identification test, Conforms	Conforms
	A reddish violet color is produced, Conforms
	Meets the requirements of the test for Sulfate, Conforms
PH (2%)	5.0～7.0	6.5
Specific optical rotation	-78°～-90°	-83°
Loss on drying	≤6.0%	3.1%
Sulfated ash	≤0.75%	0.26%
Sulfate	15.5%～17.5%	15.8%
Related substances, HPLC	Any impurity: ≤3.0% Sum of impurity: ≤17.0%	2.6% 10.1%
Heavy metals	≤20 ppm	Conform
Total viable aerobic count	≤100 CFU/g	Conforms
Potency (Dried basis)	≥6000 IU/mg	7924 IU/mg
Assay HPLC (Dried basis)	Sum of polymyxin B1, B2, B3 and B1-I: ≥80.0% Polymyxin B3: ≤6.0% Polymyxin B1-I: ≤15.0%	89.1% 2.0% 10.4%

Polymyxin B Sulfate CAS 1405-20-5

Product: Polymyxin B Sulfate CAS 1405-20-5
Chemical Name: Polymyxin B, sulfate (salt); Polymyxin B; Polymyxin-B-Sulfat; Sulfato De Polimixina B; Polymyxin B (PMB); PMB; Polymyxin B sulfate USP; Polymyxin B Sulfate 1405-20-5; Einecs 215-774-7;
CAS No.: 1405-20-5
Physical characteristics: It is a white crystalline powder, readily soluble in water, and possesses hygroscopic properties.
Molecular Formula: C₅₆H₁₀₀N₁₆O₁₇S
Molecular Weight: 1301.5552
MDL Number: MFCD30489731
NSC Number: 757278

Polymyxin B sulfate, with CAS number 1405-20-5, is an antibiotic medication that offers several benefits in the treatment of bacterial infections. Here are some of the benefits of Polymyxin B Sulfate:

1. Effective against Gram-Negative Bacteria: Polymyxin B sulfate is primarily used to treat infections caused by Gram-negative bacteria. It is particularly effective against multidrug-resistant strains, including Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. These bacteria are often associated with hospital-acquired infections and can be challenging to treat with other antibiotics.

2. Topical Treatment for Skin Infections: Polymyxin B sulfate is commonly used as a topical antibiotic for the treatment of skin infections, such as infected wounds, burns, and impetigo. It helps eliminate or control bacterial growth at the site of infection, preventing the spread of infection and promoting healing.

3. Treatment of Eye Infections: Polymyxin B sulfate is also utilized in ophthalmic preparations for the treatment of eye infections, including conjunctivitis and keratitis caused by susceptible bacteria. It helps eradicate bacterial pathogens in the eye, relieving symptoms and preventing complications.

4. Combination Therapy for Respiratory Infections: Polymyxin B sulfate is sometimes used in combination with other antibiotics, such as carbapenems, to treat severe respiratory infections caused by multidrug-resistant Gram-negative bacteria, including those associated with ventilator-associated pneumonia or cystic fibrosis.

5. Limited Systemic Absorption: When used topically or as eye drops, Polymyxin B sulfate has limited systemic absorption, reducing the risk of systemic side effects. It primarily acts at the site of infection, helping to minimize the impact on other parts of the body.

6. Synergistic Effect with Other Antibiotics: Polymyxin B sulfate exhibits a synergistic effect when used in combination with certain antibiotics, such as carbapenems or tetracyclines. This means that the combination of drugs can enhance the overall antibacterial activity, making it more effective against difficult-to-treat infections.

1. Payment term

TT, LC

2. Delivery date

Negotiable

3. Market

Middle East / Africa / Asia / South America / Europe

4. Sample

Available
5. Executive standards
CP, EP, IP

6. Qualification certificate
Registration "A" status of raw material packaging, Notification of Approval of marketing application for chemical API, WC, COPP, CEP, EUGMP, US DMF registration number, India Registration certificate, Brazil registration, Malaysia registration, etc.

7. Packaging size specification

Inner package: single-layer polyethylene bag and aluminum foil bag.

Outer package: fiber drum.

Packaging size: 25 kg/drum; 1kg/drum; 5kg/drum.

We have branch offices in Dubai and India

we have own reliable & Long-term cooperative & experienced factory

Variety products for selection from China and India

We can customize according to your requirements

We can do OEM & ODM

We can offer N-1 to API

Hot Tags: polymyxin b sulfate cas 1405-20-5, China polymyxin b sulfate cas 1405-20-5 manufacturers, suppliers, factory, antibiotics api for jointly developing new products with suppliers, antibiotics api for partnering on market expansion with suppliers, antibiotics api for working together on cost reduction with suppliers