Prilocaine Hydrochloride CAS 1786-81-8

Prilocaine Hydrochloride CAS 1786-81-8
Details:
Product: Prilocaine hydrochloride CAS 1786-81-8
Alternative Names: Prilocaine Hydrochloride; Prilocaine; Prilocaine HCl; Citanest API; Prilocaine Monohydrochloride; 721-50-6; 1786-81-8;
Chemical Name: 2-(Propylamino)-o-propionotoluidide hydrochloride;
Molecular formula: C13H21ClN2O
Molecular mass: 256.77
CAS No.: 1786-81-8
MDL Number: MFCD00079279
EINECS Number: 217-244-0
Biological activity: Prilocaine hydrochloride is used for local nerve block and for spinal anesthesia; pharmacological properties are similar to those of lidocaine.
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Description
Technical Parameters

Prilocaine hydrochloride CAS 1786-81-8, is a white crystalline powder that is easily soluble in water and ethanol, slightly soluble in chloroform, and insoluble in ether. Ropivacaine hydrochloride belongs to the amide-type local anesthetics and is used for epidural anesthesia, nerve block anesthesia, and infiltration anesthesia, among others. It has a similar anesthetic potency and onset speed as lidocaine but has a longer duration of action and lower toxicity compared to lidocaine. Ropivacaine is rapidly metabolized, resulting in less accumulation in the body.

 

Prilocaine hydrochloride CAS 1786-81-8
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Product: Prilocaine hydrochloride CAS 1786-81-8

Alternative Names: Prilocaine Hydrochloride; Prilocaine; Prilocaine HCl; Citanest API; Prilocaine Monohydrochloride; 721-50-6; 1786-81-8;

Chemical Name: 2-(Propylamino)-o-propionotoluidide hydrochloride;

Molecular formula: C13H21ClN2O

Molecular mass: 256.77
CAS No.: 1786-81-8

MDL Number: MFCD00079279

EINECS Number: 217-244-0

Biological activity: Prilocaine hydrochloride is used for local nerve block and for spinal anesthesia; pharmacological properties are similar to those of lidocaine.

Here are some common applications of Prilocaine hydrochloride:

1. Local Anesthesia: Prilocaine hydrochloride is primarily used as a local anesthetic. It is administered topically or through injection to induce a reversible loss of sensation in a specific area of the body, thereby providing pain relief during medical and dental procedures. Prilocaine hydrochloride blocks nerve signals in the area where it is applied, leading to temporary numbness and reduced pain sensations.

2. Infiltration Anesthesia: Prilocaine hydrochloride is commonly used for infiltration anesthesia, which involves injecting the local anesthetic solution into the tissues near the site of the procedure. It is effective in providing anesthesia for minor surgical procedures, biopsies, suturing wounds, and other interventions that require local numbing.

3. Nerve Block Anesthesia: Prilocaine hydrochloride is also utilized for nerve block anesthesia. In this technique, the local anesthetic is injected near a specific nerve or group of nerves to numb a larger area of the body. Nerve block anesthesia is commonly used for surgeries, such as orthopedic procedures, regional anesthesia, and pain management.

4. Topical Analgesia: Prilocaine hydrochloride may be used topically as a cream or gel to provide pain relief for conditions such as sunburns, minor burns, insect bites, or skin irritations. When applied to the affected area, it numbs the skin and reduces pain or itching sensations.

 

1. Payment term

TT, LC

2. Delivery date

Negotiable

3. Market

Middle East / Africa / Asia / South America / Europe

4. Sample

Available
5. Executive standards
EP/USP/JP

6. Qualification certificate

Registration "A" status of raw material packaging, Notification of Approval of marketing

7. Packaging size specification

Inner package: single-layer polyethylene bag and aluminum foil bag.

Outer package: fiber drum.

Packaging size: 25 kg/drum.

 

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Prilocaine hydrochloride CAS 1786-81-8 API FAQ

 

Q: Is prilocaine used for nerve block?

A: Prilocaine has a clinical profile similar to lidocaine and is used for infiltration, peripheral nerve blocks, and spinal and epidural anesthesia.

Q: What is the difference between lidocaine and prilocaine?

A: While having the disadvantage of inducing methemoglobinemia, prilocaine has the advantage of lower cardio- and neurotoxicity compared to lidocaine.

Q: Is prilocaine stronger than benzocaine?

A: Topical anesthetics based on a combination of lidocaine 2.5% + prilocaine 2.5% are significantly more effective than 20% benzocaine in reducing pain from needle stick in the maxillary vestibular mucosa.

Q: What class of drug is prilocaine?

A: Prilocaine is an Amide Local Anesthetic.

Q: What type of drug is prilocaine?

A: Prilocaine is a local anesthetic used in dental procedures.

Q: How long does prilocaine take to work?

A: Satisfactory dermal analgesia is achieved 1 hour after application, reaches maximum at 2 to 3 hours, and persists for 1 to 2 hours after removal. Absorption from the genital mucosa is more rapid and onset time is shorter (5 to 10 minutes) than after application to intact skin.

Q: What is Prilocaine hydrochloride used for?

A: Prilocaine hydrochloride is indicated in adults and children aged above 6 months as a local anaesthetic for use in infiltration anaesthesia and nerve blocks. Care should be taken to prevent toxic reactions by avoiding intravascular injection. Careful aspiration before and during the injection is recommended.

Q: What is the potency of prilocaine?

A: Prilocaine is an amide LA with a similar potency profile to lidocaine, with a rapid onset of action and intermediate duration of action. Prilocaine does not produce vasodilatation and has rapid hepatic metabolism and low toxicity .

Q: What is prilocaine known to cause?

A: This medicine may cause a rare, but serious blood problem called methemoglobinemia. The risk may be increased in children younger than 6 months of age, elderly patients, or patients with certain inborn defects.

Q: Is prilocaine long acting?

A: Prilocaine is an amide-type local anesthetic characterized by intermediate potency and duration and fast onset of action.

Q: How long does prilocaine plain last?

A: In clinical studies, this has been found to provide complete anesthesia for procedures lasting an average of 20 minutes.

 

 

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