Synthesis Method
Obtained from the direct cracking of castor oil or by ester exchange cracking.
1. The direct cracking method of castor oil involves placing castor oil into a stainless steel reaction kettle, heating it directly, and conducting pyrolysis under reduced pressure. The distillate is collected, and then fractionated to obtain undecenoic acid, while also producing heptanoic acid.
2. The ester exchange method of castor oil involves the ester exchange of castor oil (castor oil glyceride) with methanol, followed by high-temperature cracking to obtain methyl undecenoate. After saponification and acid purification, the final product is obtained, alongside by-products such as heptanal and glycerol.
Product Use
1. An important raw material for synthetic fragrances, such as the production of γ-decalactone (also known as peach aldehyde), polycyclic decanolide, muscone, nonanal, nonanol, etc.
2. Can also be used in antifungal drugs and medications for treating skin fungal infections, capable of synthesizing antimicrobial surfactants such as sodium succinate ester of oleyl ethanolamide.
3. Also used in the preparation of plasticizers, etc. The maximum allowable concentration in cosmetics (mass fraction) is 0.2%, stable within the pH range of 5.0 to 6.5. The dosage for use as an antifungal agent in medicines (mass fraction) is 2% to 15%.
【Formulation/Specification】
① Ointment: 20%. ② Athlete's foot cream (contains this product 20%, zinc undecylenate 5%). ③ Undecylenic acid ethanol solution (Mingxing antifungal solution): 10%.
【Dosage and Administration】 For external use. The formulation should be applied locally, and continuous use for several weeks is required for curing. The concentration for mucous membranes should not exceed 1%, applied 2-3 times a day.
【Precautions】 Local external use may cause contact dermatitis. This product is for external use only and should not be ingested; it can irritate tissues if the concentration is too high.
【Functions and Effects】This product can inhibit the proliferation of fungi. It is used to treat fungal infections of the skin such as tinea capitis, tinea cruris, tinea pedis, and fungal vaginitis. It is most effective against tinea pedis.
【Properties】This product is a pale yellow to yellow liquid that forms milky white crystalline clumps when cold; it has a strong odor. It can be mutually dissolved with ethanol, chloroform, ether, fatty oils, or volatile oils, but is almost insoluble in water. Relative Density: The relative density of this product is 0.910 to 0.913 at 25°C. Freezing Point: The freezing point of this product is no lower than 21°C. Refractive Index: The refractive index of this product is 1.448 to 1.450 at 25°C. Iodine Value: The iodine value of this product is 131 to 140.
Raw Material Workshop
Q: What is undecylenic acid mainly used to treat?
A: It is mainly used to treat skin diseases caused by fungal infections, such as athlete's foot, jock itch, and scalp fungal infections, with particularly good effects on treating athlete's foot. It can also be used for fungal vaginitis.
Q: How should this medication be used?
A: This product is for external use only and should not be taken internally. Please apply the ointment or solution directly to the affected area 2-3 times a day. It's important to note that treatment requires continuous use for several weeks for a complete cure.
Q: Are there any special precautions when using this medication?
A: There are two special points to note: First, if used on mucous membranes (such as the vagina), the drug concentration should not exceed 1% to avoid irritation. Second, the medication should be stored in a light-proof, sealed container, as it can solidify into lumps when exposed to cold and has unstable properties.
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