Description

Technical Parameters

Tadalafil, with CAS number 171596-29-5, is an active pharmaceutical ingredient (API) used in the formulation of medications primarily for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH).

Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor. It works by blocking the action of the enzyme PDE5, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis and pulmonary arteries. By inhibiting PDE5, tadalafil allows for the relaxation of smooth muscles and increased blood flow, leading to improved erectile function and pulmonary vasodilation.

Tadalafil CAS 171596-29-5

Product: Tadalafil CAS 171596-29-5
Alternative Names: Tadalafil API; Cialis Tadalafil API; Adcirca API; CAS 171596-29-5; 171596-29-5; IC 351; ICOS351; Cialis 98%; Tildenafil; UK 336017;
Chemical Name: (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Molecular formula: C₂₂H₁₉N₃O₄
Molecular mass: 389.41
CAS No.: 171596-29-5
MDL Number: MFCD07771966
Tadalafil Intermediates: CAS: 156-83-2; CAS: 171752-68-4; CAS: 14907-27-8

The primary indications and uses of tadalafil include:

1. Erectile Dysfunction (ED): Tadalafil is commonly prescribed for the treatment of erectile dysfunction, a condition characterized by the inability to achieve or maintain an erection sufficient for sexual activity. It helps promote penile erection by enhancing the effects of nitric oxide, a chemical that relaxes the smooth muscles and increases blood flow to the penis during sexual stimulation.

2. Pulmonary Arterial Hypertension (PAH): Tadalafil is also approved for the treatment of pulmonary arterial hypertension, a condition characterized by high blood pressure in the arteries that supply the lungs. By relaxing the smooth muscles in the pulmonary arteries, tadalafil improves blood flow and reduces the workload on the heart, resulting in improved exercise capacity and symptoms in patients with PAH.

3. Benign Prostatic Hyperplasia (BPH): In some cases, tadalafil may be prescribed for the treatment of benign prostatic hyperplasia, a condition characterized by an enlarged prostate gland. It helps relax the smooth muscles in the prostate and bladder, allowing for improved urinary flow and reducing symptoms such as frequent urination or difficulty in urination.

1. Payment term

TT, LC

2. Delivery date

Negotiable

3. Market

Middle East / Africa / Asia / South America / Europe

4. Sample

Available
5. Executive standards
EP/USP/JP

6. Qualification certificate

Registration "A" status of raw material packaging, Notification of Approval of marketing

7. Packaging size specification

Inner package: single-layer polyethylene bag and aluminum foil bag.

Outer package: fiber drum.

Packaging size: 25 kg/drum; 1kg/drum; 10kg/drum.

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Tadalafil CAS 171596-29-5 API FAQ

Q: What are the isomers of tadalafil?

A: Tadalafil has 4 isomers [(RR), (SS), (RS), and (SR)], of which (RR) is the name-sake isomer and potent inhibitor of phosphodiesterase-5.

Q: How is tadalafil made?

A: The invention relates to a preparation method of tadalafil. A product is obtained through condensation and cyclization, chloromethylation and aminolysis cyclization reaction based on D-tryptophan methyl ester hydrochloride and heliotropin as starting preparation materials.

Q: What is the melting point of tadalafil?

A: Properties: White crystals from 2-propanol, mp 302-303°.

Q: Does tadalafil keep you hard after coming?

A: If you're taking it for erectile dysfunction, you should be able to get an erection at any time between 30 minutes and 36 hours after taking tadalafil. You need to be sexually excited for it to work. Your erection should go away after you have had sex.

Q: Is tadalafil used for anything other than ED?

A: This medicine is also used to treat erectile dysfunction and signs and symptoms of BPH. Tadalafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension to improve your ability to exercise.

Q: Can I drink with tadalafil?

A: First, it's good to remember that both alcohol and Cialis lower your blood pressure, so combining them can increase that effect, sometimes dangerously. Low blood pressure can lead to dizziness, headaches, and rapid heartbeats.

Q: What does tadalafil do to a woman?

A: A small study from 2012 found that a daily tadalafil dose of 5 mg improved sexual dysfunction in women with type 1 diabetes (Caruso, 2012). A 2017 review of sexual dysfunction treatments in menopausal women speculated that tadalafil could successfully treat sexual conditions in postmenopausal women

Q: What happens if I take tadalafil daily?

A: Research has consistently concluded that daily tadalafil is safe and well-tolerated by most people. Because of the small doses, there are fewer side effects associated with tadalafil daily compared to regular, as-needed tadalafil and sildenafil.

Q: How long does tadalafil keep you erect?

A: PDE5 destroys cGMP, so a PDE5 inhibitor drug stops that, to ensure the cGMP can do its job properly and help keep you up. Known as the "weekend pill" because it is effective for up to 36 hours.

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