Description

Technical Parameters

Metronidazole CAS 443-48-1 is an antibiotic and antiprotozoal agent used for the treatment or prevention of systemic or localized infections caused by anaerobic bacteria. It is effective against anaerobic bacterial infections in various sites such as the abdominal cavity, gastrointestinal tract, female reproductive system, lower respiratory tract, skin and soft tissues, bones, and joints. It is also effective in treating sepsis, endocarditis, meningitis, and antibiotic-associated colitis. Metronidazole is often used in combination with tetanus antitoxin (TAT) for the treatm

Identification
A: Melting point (℃) B: UV Absorbance -Maximum -Minimum -Specific absorbance of maximum	159～163 277nm 240nm 365-395	160.8~161.1 Conforms Conforms Conforms
C: IR absorption	The sample spectrum complies with that of the reference standard spectrum.	Conforms
D: Reaction of primary aromatic amines	The sample solution gives the reaction of primary aromatic amines.	Conforms
Appearance of solution -Limpidity - Coloration degree (Method II)	The solution is not more opalescent than reference suspensions II.	Conforms
	The solution is not more intensely coloured than reference solution GY6.	Conforms
Related Substances (HPLC)
Any other unknown impurity, %	≤0.1	0.01
Total Impurities, %	≤0.2	0.02
Loss on drying (%)	≤0.5	0.2
Sulphated ash (%)	≤0.1	0.04
Heavy metals	≤20ppm	Conforms
Assay (calculated on the dried substance), %	99.0～101.0	99.8
Microbiology test (cfu/g)	Total aerobic microbial count (TAMC) should be no more than 10³ in 1g	＜1×10
Bulk density (g/ml)	Total Yeasts/Moulds count (TYMC) should be no more than 10² in 1g	＜1×10
	Absence of Escherichia coli in 1g	Not detected
	≥0.7	Conforms

Metronidazole CAS 443-48-1

Product: Metronidazole 443-48-1
CAS No.: 443-48-1
Chemical Name: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol;
Another Name: Metronidazole API; Metrogel API; Metronidazole HCl; Metoclopramide HCL API; Metronidazole Hydrochloride; CAS 443-48-1; MNZ; 2-Methyl-5-nitroimidazole-1-ethanol; 2-Methyl-5-nitroimidazole-1-ethanol 443-48-1;
Physical characteristics: Soluble in hot water, slightly soluble in ethanol, slightly soluble in water or chloroform, and very slightly soluble in ether. It has a bitter and slightly salty taste.
Molecular Formula: C₆H₉N₃O₃
Molecular Weight: 171.1540
MDL Number: MFCD00009750

Metronidazole, with CAS number 443-48-1, is an antimicrobial medication that offers several benefits in the treatment of various infections. Here are some of the benefits of Metronidazole:

1. Broad-Spectrum Antimicrobial Activity: Metronidazole exhibits broad-spectrum activity against a wide range of bacteria and parasites. It is effective against anaerobic bacteria, including certain strains of Clostridium, Bacteroides, and Helicobacter pylori. It is also active against protozoa, such as Trichomonas vaginalis, Giardia lamblia, and Entamoeba histolytica.

2. Treatment of Bacterial Infections: Metronidazole is commonly used to treat infections caused by anaerobic bacteria. It is particularly effective in the treatment of intra-abdominal infections, gynecological infections (such as bacterial vaginosis), and certain types of dental and periodontal infections. It can also be used to treat certain skin and soft tissue infections.

3. Treatment of Protozoal Infections: Metronidazole is highly effective against various protozoal infections. It is commonly used to treat trichomoniasis, a sexually transmitted infection caused by Trichomonas vaginalis. Additionally, it is effective in treating infections caused by Giardia lamblia, a parasite that can cause gastrointestinal symptoms, and Entamoeba histolytica, the causative agent of amoebiasis.

4. Prevention of Surgical Infections: Metronidazole is often used as a prophylactic antibiotic in surgical procedures where anaerobic infections are a concern. It helps prevent surgical site infections and reduces the risk of postoperative complications in certain surgical settings, such as colorectal and gynecological surgeries.

5. Combination Therapy for Helicobacter pylori Infection: Helicobacter pylori is a bacterium associated with gastric ulcers and certain types of stomach cancer. Metronidazole is frequently used in combination with other antibiotics, such as amoxicillin or clarithromycin, as part of a multidrug regimen for the eradication of Helicobacter pylori.

6. Well-Tolerated and Cost-Effective: Metronidazole is generally well-tolerated by most patients. Common side effects, when they occur, are usually mild and include gastrointestinal symptoms, such as nausea, diarrhea, and metallic taste. Additionally, metronidazole is often available as a low-cost generic medication, making it a cost-effective option for many patients.

1. Payment term

TT, LC

2. Delivery date

Negotiable

3. Market

Middle East / Africa / Asia / South America / Europe

4. Sample

Available
5. Executive standards
CP, EP, IP

6. Qualification certificate
Registration "A" status of raw material packaging, Notification of Approval of marketing application for chemical API, WC, COPP, CEP, EUGMP, US DMF registration number, India Registration certificate, Brazil registration, Malaysia registration, etc.

7. Packaging size specification

Inner package: single-layer polyethylene bag and aluminum foil bag.

Outer package: fiber drum.

Packaging size: 25 kg/drum.

Our Advantage

1. We have branch offices in Dubai and India

2. We have own reliable & Long-term cooperative & experienced factory

3. Variety products for selection from China and India

4. We can customize according to your requirements

5. We can do OEM & ODM

6. We can offer N-1 to API

Metronidazole API FAQ

Q: Is metronidazole stronger than penicillin?

A: Metronidazole is an antibiotic that is effective against certain types of bacteria and parasites. It works by interfering with the DNA of these microorganisms, preventing their growth and replication. It is commonly used to treat infections such as bacterial vaginosis, certain types of gastrointestinal infections, and dental infections.
The choice between metronidazole and penicillin, or any other antibiotic, depends on the specific infection being treated, the type of bacteria involved, and other factors such as the patient's allergies or tolerances to certain medications. The effectiveness of an antibiotic can vary depending on the specific situation. It is important to consult with a healthcare professional who can evaluate the individual case and prescribe the most appropriate treatment.

Q: Why can't you eat bananas with metronidazole?

A: Metronidazole can interfere with the metabolic process of alcohol in the body, leading to the accumulation of acetaldehyde and causing a disulfiram-like reaction. This can result in symptoms such as nausea, vomiting, or a metallic taste in the mouth.
As for the amine compounds in bananas, including tyramine, they are believed to potentially interact with medications. Amine compounds can interfere with the activity of specific enzymes, thereby affecting the metabolism and excretion of drugs.

Q: How quickly does metronidazole work?

A: In general, metronidazole starts to work relatively quickly, usually within a few hours to a couple of days.
For certain infections, such as bacterial vaginosis or trichomoniasis, symptoms may begin to improve within a day or two of starting metronidazole treatment.
For other conditions, such as certain types of anaerobic bacterial infections or protozoal infections, it may take several days to a week or more for metronidazole to effectively control the infection and alleviate symptoms.

Q: Why can't you eat chocolate while taking metronidazole?

A: Metronidazole inhibits the breakdown of tyramine in the body, which can result in increased levels of tyramine in the bloodstream. If a person consumes foods high in tyramine, such as chocolate, while taking metronidazole, it can potentially trigger a hypertensive crisis, characterized by symptoms like severe headache, rapid heart rate, chest pain, and sweating.

Q: What are some common side effects of metronidazole that I should be aware of?

A: 1. Gastrointestinal Effects: Nausea, vomiting, and diarrhea are the most commonly reported side effects of metronidazole. These symptoms are usually mild and may improve as your body adjusts to the medication. Taking the medication with food or a full glass of water can help alleviate gastrointestinal discomfort.
2. Metallic Taste: Some people may experience a metallic or bitter taste in their mouth while taking metronidazole. This taste disturbance is temporary and generally resolves after finishing the course of medication.
3. Dry Mouth: Metronidazole can cause dryness in the mouth. Staying hydrated by drinking plenty of fluids and practicing good oral hygiene can help manage this side effect.
4. Dizziness: Metronidazole may cause dizziness or lightheadedness in some individuals. It is advisable to avoid activities that require alertness, such as driving or operating machinery, if you experience these symptoms.
5. Allergic Reactions: While rare, allergic reactions to metronidazole can occur. Seek immediate medical attention if you develop symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing.

Q: Who Cannot take metronidazole?

A: 1. Allergic Reactions: Individuals who have a known hypersensitivity or allergic reaction to metronidazole or any of its components should avoid taking the medication.
2. Blood Disorders: People with a history of blood disorders, such as a low white blood cell count or a history of blood dyscrasias, should exercise caution and discuss their condition with a healthcare provider before using metronidazole.
3. Liver Disease: Metronidazole is primarily metabolized by the liver, so individuals with severe liver disease or impaired liver function may require dosage adjustments or alternative treatment options.
4. Pregnancy and Breastfeeding: Metronidazole should be used with caution during pregnancy, especially during the first trimester.

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